Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia-reperfusion injury

DOI Web Site 4 Citations
  • Aleksandra Stamenkovic
    Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
  • Kimberley A. O’Hara
    Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
  • David C. Nelson
    Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
  • Thane G. Maddaford
    Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
  • Andrea L. Edel
    Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
  • Graham Maddaford
    Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
  • Elena Dibrov
    Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
  • MohamadReza Aghanoori
    Department of Pharmacology and Therapeutics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
  • Lorrie A. Kirshenbaum
    Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
  • Paul Fernyhough
    Department of Pharmacology and Therapeutics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
  • Michel Aliani
    Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada
  • Grant N. Pierce
    Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
  • Amir Ravandi
    Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada

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<jats:p> Oxidized phosphatidylcholines (OxPC) generated during reperfusion injury are potent inducers of cardiomyocyte death. Our studies have shown that OxPCs exert this effect through a ferroptotic process that can be attenuated. A better understanding of the OxPC cell death pathway can prove a novel strategy for prevention of cell death during myocardial reperfusion injury. </jats:p>

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