Iron-sulfur cluster deficiency can be sensed by IRP2 and regulates iron homeostasis and sensitivity to ferroptosis independent of IRP1 and FBXL5
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- Erdem M. Terzi
- Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
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- Vladislav O. Sviderskiy
- Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
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- Samantha W. Alvarez
- Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
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- Gabrielle C. Whiten
- Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
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- Richard Possemato
- Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
説明
<jats:p>Iron-sulfur clusters enable cells to sense that they have the right amount of iron, and protect them from self-destruction.</jats:p>
収録刊行物
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- Science Advances
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Science Advances 7 (22), eabg4302-, 2021-05-28
American Association for the Advancement of Science (AAAS)