Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/9

DOI Web Site Web Site 2 Citations
  • Yu Sawada
    Department of Dermatology, University of California, San Diego, San Diego, CA, USA.
  • Teruaki Nakatsuji
    Department of Dermatology, University of California, San Diego, San Diego, CA, USA.
  • Tatsuya Dokoshi
    Department of Dermatology, University of California, San Diego, San Diego, CA, USA.
  • Nikhil Nitin Kulkarni
    Department of Dermatology, University of California, San Diego, San Diego, CA, USA.
  • Marc C. Liggins
    Department of Dermatology, University of California, San Diego, San Diego, CA, USA.
  • George Sen
    Department of Dermatology, University of California, San Diego, San Diego, CA, USA.
  • Richard L. Gallo
    Department of Dermatology, University of California, San Diego, San Diego, CA, USA.

Description

<jats:p>Inhibition of HDAC8 and HDAC9 impairs keratinocyte tolerance of TLR ligand stimulation, leading to cutaneous inflammation.</jats:p>

Journal

  • Science Immunology

    Science Immunology 6 (59), 2021-05-28

    American Association for the Advancement of Science (AAAS)

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