Role of Dietary Polyphenols in Adipose Tissue Browning: A Narrative Review

  • Juan Salazar
    Endocrine and Metabolic Diseases Research Center. School of Medicine, University of Zulia, Maracaibo, Venezuela
  • Clímaco Cano
    Endocrine and Metabolic Diseases Research Center. School of Medicine, University of Zulia, Maracaibo, Venezuela
  • José L. Pérez
    Endocrine and Metabolic Diseases Research Center. School of Medicine, University of Zulia, Maracaibo, Venezuela
  • Ana Castro
    Endocrine and Metabolic Diseases Research Center. School of Medicine, University of Zulia, Maracaibo, Venezuela
  • María P. Díaz
    Endocrine and Metabolic Diseases Research Center. School of Medicine, University of Zulia, Maracaibo, Venezuela
  • Bermary Garrido
    Endocrine and Metabolic Diseases Research Center. School of Medicine, University of Zulia, Maracaibo, Venezuela
  • Rubén Carrasquero
    Endocrine and Metabolic Diseases Research Center. School of Medicine, University of Zulia, Maracaibo, Venezuela
  • Maricarmen Chacín
    Universidad Simon Bolivar, Facultad de Ciencias de la Salud, Barranquilla, Colombia
  • Manuel Velasco
    Universidad Central de Venezuela, Escuela de Medicina Jose Maria Vargas, Caracas, Venezuela
  • Luis D´Marco
    Hospital Clínico Universitario, INCLIVA, Nephrology department, Valencia, Spain
  • Joselyn Rojas-Quintero
    Pulmonary and Critical Care Medicine Department, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, United States
  • Valmore Bermúdez
    Universidad Simon Bolivar, Facultad de Ciencias de la Salud, Barranquilla, Colombia

抄録

<jats:sec> <jats:title /> <jats:p>Lifestyle modifications such as energy restriction and increased physical activity are highly effective in the management of obesity. However, adherence to these therapeutic approaches is poor. On the other hand, synthetic drugs used for obesity control are plagued by adverse effects. Despite these failures, adipose tissue is still an attractive therapeutic target for novel molecules, and thus, the characterisation of new and safer anti-obesity drugs is of significant interest. For this reason, in recent years, phenolic constituents of diverse plants have drawn much attention due to their health-promoting properties, opening new research lines related to brown adipose tissue activation and white adipose tissue (WAT) browning. The goal is to increase energy expenditure levels through thermogenic activity activation by multiple factors, like polyphenols. The suggested mechanisms by which polyphenols can modulate thermogenesis include Nor-epinephrine/Catechol-O-Methyl-Transferase (NE/COMT) inhibition, PPAR&#947; co-activator alpha (PGC-1&#945;)-dependent pathways activation, and mitochondrial biogenesis, among others. Although polyphenols such as quercetin, catechins, chrysin, luteolin, curcumin, resveratrol, gallic acid, and lignans have shown a positive effect on Non-Shivering Thermogenesis and WAT browning, most of them have only been active in murine models or in vitro systems, and their reproducibility in humans has to be proved. Probably in the future, an approach that includes these compounds as part of the nutritional regimen in conjunction with physical exercise, pharmacological and surgical therapy, would allow modulating a pathophysiological mechanism that is still elusive.</jats:p> </jats:sec>

収録刊行物

被引用文献 (1)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ