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- Vignesh Sivaganesh
- Department of Biological Sciences, University of the Sciences, 600 S 43rd St, Philadelphia, PA 19104, USA
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- Varsha Sivaganesh
- Department of Biological Sciences, University of the Sciences, 600 S 43rd St, Philadelphia, PA 19104, USA
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- Christina Scanlon
- Department of Biological Sciences, University of the Sciences, 600 S 43rd St, Philadelphia, PA 19104, USA
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- Alexander Iskander
- Department of Biological Sciences, University of the Sciences, 600 S 43rd St, Philadelphia, PA 19104, USA
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- Salma Maher
- Department of Biological Sciences, University of the Sciences, 600 S 43rd St, Philadelphia, PA 19104, USA
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- Thư Lê
- Department of Biological Sciences, University of the Sciences, 600 S 43rd St, Philadelphia, PA 19104, USA
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- Bela Peethambaran
- Department of Biological Sciences, University of the Sciences, 600 S 43rd St, Philadelphia, PA 19104, USA
説明
<jats:p>Protein tyrosine kinases, especially receptor tyrosine kinases, have dominated the cancer therapeutics sphere as proteins that can be inhibited to selectively target cancer. However, protein tyrosine phosphatases (PTPs) are also an emerging target. Though historically known as negative regulators of the oncogenic tyrosine kinases, PTPs are now known to be both tumor-suppressive and oncogenic. This review will highlight key protein tyrosine phosphatases that have been thoroughly investigated in various cancers. Furthermore, the different mechanisms underlying pro-cancerous and anti-cancerous PTPs will also be explored.</jats:p>
収録刊行物
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- International Journal of Molecular Sciences
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International Journal of Molecular Sciences 22 (23), 12865-, 2021-11-28
MDPI AG
