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- Hang Shi
- Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, School of Science, Westlake University
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- Qi-Kai Kang
- Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, School of Science, Westlake University
書誌事項
- 公開日
- 2021-01-14
- DOI
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- 10.1055/a-1354-0367
- 公開者
- Georg Thieme Verlag KG
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>The introduction of deuterium and tritium into molecules is of great importance in drug discovery. Many attempts have been made to develop late-stage hydrogen isotope exchange (HIE) reactions to avoid multistep syntheses using commercially available labeled precursors. In this review, we summarize recent progress in catalytic HIE reactions, with our main focus on their applications in the late-stage labeling of bioactive complex molecules and pharmaceuticals1 Introduction</jats:p><jats:p>2 Non-Transition-Metal-Catalyzed Hydrogen Isotope Exchange</jats:p><jats:p>2.1 Organocatalysis</jats:p><jats:p>2.2 Photoredox Catalysis</jats:p><jats:p>3 Transition-Metal-Catalyzed Hydrogen Isotope Exchang</jats:p><jats:p>3.1 Palladium</jats:p><jats:p>3.2 Ruthenium</jats:p><jats:p>3.3 Iridium</jats:p><jats:p>3.4 Other Metals</jats:p><jats:p>4 Summary</jats:p>
収録刊行物
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- Synlett
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Synlett 33 (04), 329-338, 2021-01-14
Georg Thieme Verlag KG
