Electrically Evoked Potentials Are Reduced Compared to Axon Numbers in Rhodopsin P347L Transgenic Rabbits With Severe Photoreceptor Degeneration
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- Taro Kominami
- Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan
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- Shinji Ueno
- Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan
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- Kentaro Nishida
- Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan
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- Daiki Inooka
- Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan
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- Azusa Kominami
- Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan
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- Mineo Kondo
- Department of Ophthalmology, Mie University Graduate School of Medicine, Tsu, Japan
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- Hiroko Terasaki
- Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan
書誌事項
- 公開日
- 2019-06-17
- 資源種別
- journal article
- 権利情報
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- http://creativecommons.org/licenses/by-nc-nd/4.0/
- DOI
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- 10.1167/iovs.19-26972
- 公開者
- Association for Research in Vision and Ophthalmology (ARVO)
この論文をさがす
説明
To determine the relationship between the amplitudes of the electrically evoked potentials (EEPs) and the number of optic nerve axons at a late stage of retinal degeneration in rhodopsin P347L transgenic (Tg) rabbits, a model of retinitis pigmentosa.Six eyes of six wild-type (WT) (43.8 ± 7.5 months of age) and six eyes of six Tg (40.3 ± 2.6 months of age) rabbits were studied. The EEPs were elicited by 1 to 5 mA of transcorneal electrical stimulation. The first positive wave, the P1 component, was analyzed. After euthanasia, the number of axons in the optic nerve was counted.The threshold current to elicit a P1 was significantly higher in Tg rabbits than WT rabbits. The amplitude of P1 elicited by 5 mA in Tg rabbits was about 24% of that in WT rabbits (P0.01). The number of axons in the optic nerve of Tg rabbits was reduced to about 59% of that of WT rabbits (P0.01). The correlation between the axon number and the amplitude of the P1 in Tg and WT rabbits was not significant. The mean ratio of the P1 amplitude/axon in Tg rabbits was decreased to 53% of that in WT rabbits (P0.05).The degree of reduction in the EEP in Tg rabbits is more severe than the reduction in the number of optic nerve axons. The use of transcorneal electrical stimulation to determine the suitable candidates for prosthesis at the end-stage of retinitis pigmentosa may underestimate the condition of the optic nerves.
収録刊行物
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- Investigative Opthalmology & Visual Science
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Investigative Opthalmology & Visual Science 60 (7), 2543-, 2019-06-17
Association for Research in Vision and Ophthalmology (ARVO)
