Cellular and molecular mechanisms regulating neuronal growth by brain‐derived neurotrophic factor

DOI Web Site Web Site 被引用文献2件
  • Andres Gonzalez
    MINREB and Center for Ageing and Regeneration (CARE UC), Faculty of Biological Sciences, Department of Physiology, Pontificia Universidad Católica de Chile Santiago Chile
  • Guillermo Moya‐Alvarado
    MINREB and Center for Ageing and Regeneration (CARE UC), Faculty of Biological Sciences, Department of Physiology, Pontificia Universidad Católica de Chile Santiago Chile
  • Christian Gonzalez‐Billaut
    Laboratory of Cell and Neuronal Dynamics, Department of Biology, Faculty of Sciences, Universidad de Chile and Geroscience Center for Brain Health and Metabolism Santiago Chile
  • Francisca C. Bronfman
    MINREB and Center for Ageing and Regeneration (CARE UC), Faculty of Biological Sciences, Department of Physiology, Pontificia Universidad Católica de Chile Santiago Chile

抄録

<jats:p>Brain‐derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic and axonal growth during development and maintenance of the mature nervous system; however, the cellular and molecular mechanisms underlying this process are not fully understood. In recent years, several advances have shed new light on the processes behind the regulation of BDNF‐mediated structural plasticity including control of neuronal transcription, local translation of proteins, and regulation of cytoskeleton and membrane dynamics. In this review, we summarize recent advances in the field of BDNF signaling in neurons to induce neuronal growth. © 2016 Wiley Periodicals, Inc.</jats:p>

収録刊行物

  • Cytoskeleton

    Cytoskeleton 73 (10), 612-628, 2016-06-13

    Wiley

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