Menopause accelerates biological aging

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  • Morgan E. Levine
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095;
  • Ake T. Lu
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095;
  • Brian H. Chen
    Longitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892;
  • Dena G. Hernandez
    Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892;
  • Andrew B. Singleton
    Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892;
  • Luigi Ferrucci
    Longitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892;
  • Stefania Bandinelli
    Geriatric Unit, Azienda Sanitaria di Firenze, 50100; Florence, Italy;
  • Elias Salfati
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305;
  • JoAnn E. Manson
    Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115;
  • Austin Quach
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095;
  • Cynthia D. J. Kusters
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA 90095;
  • Diana Kuh
    Medical Research Council Unit for Lifelong Health and Ageing, University College London, London WC1B 5JU, United Kingdom;
  • Andrew Wong
    Medical Research Council Unit for Lifelong Health and Ageing, University College London, London WC1B 5JU, United Kingdom;
  • Andrew E. Teschendorff
    Department of Women’s Cancer, University College London, London WC1 6BT, United Kingdom;
  • Martin Widschwendter
    Department of Women’s Cancer, University College London, London WC1 6BT, United Kingdom;
  • Beate R. Ritz
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA 90095;
  • Devin Absher
    HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806;
  • Themistocles L. Assimes
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305;
  • Steve Horvath
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095;

Description

<jats:title>Significance</jats:title> <jats:p>Within an evolutionary framework, aging and reproduction are intrinsically linked. Although both laboratory and epidemiological studies have observed associations between the timing of reproductive senescence and longevity, it is not yet known whether differences in the age of menopause are reflected in biomarkers of aging. Using our recently developed biomarker of aging, the “epigenetic clock,” we examined whether age at menopause is associated with epigenetic age of blood, saliva, and buccal epithelium. This is a definitive study that shows an association between age of menopause and biological aging (measured using the epigenetic clock). Our results also indicate menopause may accelerate the epigenetic aging process in blood and that age at menopause and epigenetic age acceleration share a common genetic signature.</jats:p>

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