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- Morgan E. Levine
- Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095;
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- Ake T. Lu
- Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095;
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- Brian H. Chen
- Longitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892;
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- Dena G. Hernandez
- Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892;
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- Andrew B. Singleton
- Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892;
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- Luigi Ferrucci
- Longitudinal Studies Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892;
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- Stefania Bandinelli
- Geriatric Unit, Azienda Sanitaria di Firenze, 50100; Florence, Italy;
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- Elias Salfati
- Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- JoAnn E. Manson
- Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115;
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- Austin Quach
- Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095;
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- Cynthia D. J. Kusters
- Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA 90095;
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- Diana Kuh
- Medical Research Council Unit for Lifelong Health and Ageing, University College London, London WC1B 5JU, United Kingdom;
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- Andrew Wong
- Medical Research Council Unit for Lifelong Health and Ageing, University College London, London WC1B 5JU, United Kingdom;
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- Andrew E. Teschendorff
- Department of Women’s Cancer, University College London, London WC1 6BT, United Kingdom;
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- Martin Widschwendter
- Department of Women’s Cancer, University College London, London WC1 6BT, United Kingdom;
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- Beate R. Ritz
- Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA 90095;
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- Devin Absher
- HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806;
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- Themistocles L. Assimes
- Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305;
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- Steve Horvath
- Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095;
説明
<jats:title>Significance</jats:title> <jats:p>Within an evolutionary framework, aging and reproduction are intrinsically linked. Although both laboratory and epidemiological studies have observed associations between the timing of reproductive senescence and longevity, it is not yet known whether differences in the age of menopause are reflected in biomarkers of aging. Using our recently developed biomarker of aging, the “epigenetic clock,” we examined whether age at menopause is associated with epigenetic age of blood, saliva, and buccal epithelium. This is a definitive study that shows an association between age of menopause and biological aging (measured using the epigenetic clock). Our results also indicate menopause may accelerate the epigenetic aging process in blood and that age at menopause and epigenetic age acceleration share a common genetic signature.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 113 (33), 9327-9332, 2016-07-25
Proceedings of the National Academy of Sciences