Biotransformation of Nobiletin by <i>Aspergillus </i><i>n</i><i>iger </i>and the Antimutagenic Activity of a Metabolite, 4‘-Hydroxy-5,6,7,8,3‘-pentamethoxyflavone
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- Yoshiharu Okuno
- Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosaka-shi, Osaka 577-8502, Japan
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- Mitsuo Miyazawa
- Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosaka-shi, Osaka 577-8502, Japan
書誌事項
- 公開日
- 2004-10-28
- DOI
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- 10.1021/np034007g
- 公開者
- American Chemical Society (ACS)
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説明
Biotransformation of nobiletin (1) by Aspergillus niger has been investigated, and the product obtained was determined as 4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone (2). Antimutagenic activity of compound 2 was found, which showed suppressive effects on umu gene expression of the SOS response to DNA damage in Salmonella typhimurium TA1535/pSK1002, induced by the chemical mutagens furylfuramide, MeIQ, and Trp-P-1.
収録刊行物
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- Journal of Natural Products
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Journal of Natural Products 67 (11), 1876-1878, 2004-10-28
American Chemical Society (ACS)
