Apaf-1 protein deficiency confers resistance to cytochromec–dependent apoptosis in human leukemic cells

DOI PDF 被引用文献5件
  • Li Jia
    From the Department of Haematology, St Bartholomew's and The Royal London School of Medicine and Dentistry, London, United Kingdom; and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA.
  • Srinivasa M. Srinivasula
    From the Department of Haematology, St Bartholomew's and The Royal London School of Medicine and Dentistry, London, United Kingdom; and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA.
  • Feng-Ting Liu
    From the Department of Haematology, St Bartholomew's and The Royal London School of Medicine and Dentistry, London, United Kingdom; and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA.
  • Adrian C. Newland
    From the Department of Haematology, St Bartholomew's and The Royal London School of Medicine and Dentistry, London, United Kingdom; and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA.
  • Teresa Fernandes-Alnemri
    From the Department of Haematology, St Bartholomew's and The Royal London School of Medicine and Dentistry, London, United Kingdom; and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA.
  • Emad S. Alnemri
    From the Department of Haematology, St Bartholomew's and The Royal London School of Medicine and Dentistry, London, United Kingdom; and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA.
  • Stephen M. Kelsey
    From the Department of Haematology, St Bartholomew's and The Royal London School of Medicine and Dentistry, London, United Kingdom; and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA.

書誌事項

公開日
2001-07-15
DOI
  • 10.1182/blood.v98.2.414
公開者
American Society of Hematology

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説明

<jats:p>The human leukemia cell lines K562, CEM, CEM/VLB100, human leukemic blasts, and the bladder cancer J82 cell line have different sensitivities to UV light–induced apoptosis. It is reported that resistance to UV light–induced apoptosis occurs at a point in the apoptotic pathway upstream of caspase-3 but downstream of mitochondrial cytochrome c release. It is demonstrated that the block is due to deficiency of Apaf-1, a critical member of the apoptosome. Sensitivity to apoptosis was independent of caspase-9b or XIAP (inhibitors of apoptosis proteins) expression or levels of procaspase-9. Transfection of Apaf-1 conferred sensitivity to apoptosis in resistant cells. Apaf-1 deficiency may constitute a significant mode of resistance to apoptosis in human leukemia.</jats:p>

収録刊行物

  • Blood

    Blood 98 (2), 414-421, 2001-07-15

    American Society of Hematology

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