<i>Arabidopsis</i> Type I Metacaspases Control Cell Death

  • Nuria S. Coll
    Department of Biology, 108 Coker Hall, University of North Carolina (UNC), CB 3280, Chapel Hill, NC 27599–3280, USA.
  • Dominique Vercammen
    VIB Department of Plant Systems Biology and Department of Plant Biotechnology and Genetics, Ghent University, 9052 Ghent, Belgium.
  • Andrea Smidler
    Department of Biology, 108 Coker Hall, University of North Carolina (UNC), CB 3280, Chapel Hill, NC 27599–3280, USA.
  • Charles Clover
    Department of Biology, 108 Coker Hall, University of North Carolina (UNC), CB 3280, Chapel Hill, NC 27599–3280, USA.
  • Frank Van Breusegem
    VIB Department of Plant Systems Biology and Department of Plant Biotechnology and Genetics, Ghent University, 9052 Ghent, Belgium.
  • Jeffery L. Dangl
    Department of Biology, 108 Coker Hall, University of North Carolina (UNC), CB 3280, Chapel Hill, NC 27599–3280, USA.
  • Petra Epple
    Department of Biology, 108 Coker Hall, University of North Carolina (UNC), CB 3280, Chapel Hill, NC 27599–3280, USA.

抄録

<jats:title>The Yin and Yang of Plant Caspases</jats:title> <jats:p> The function of plant metacaspases, identified by limited sequence homology to the animal caspases that control cell death, has remained elusive. <jats:bold> Coll <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="1393" related-article-type="in-this-issue" vol="330" xlink:href="10.1126/science.1194980">1393</jats:related-article> ) have now elucidated the actions of two metacaspases in the small plant <jats:italic>Arabidopsis</jats:italic> . One metacaspase, AtMC1, promoted cell death, and the other, AtMC2, acted antagonistically to stall cell death. The results help to elucidate the mechanisms by which plants control cell survival during development and defend against pathogen attack. </jats:p>

収録刊行物

  • Science

    Science 330 (6009), 1393-1397, 2010-12-03

    American Association for the Advancement of Science (AAAS)

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