Cross‐Regulation of an Artificial Metalloenzyme

Yasunori Okamoto, Thomas R. Ward

doi:10.1002/anie.201702181

Cross‐Regulation of an Artificial Metalloenzyme

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Yasunori Okamoto

Department of Chemistry University of Basel Spitalstrasse 51 4056 Basel Switzerland
Thomas R. Ward

Department of Chemistry University of Basel Spitalstrasse 51 4056 Basel Switzerland

書誌事項

公開日: 2017-05-31

権利情報

http://creativecommons.org/licenses/by-nc/4.0/

DOI

10.1002/anie.201702181

公開者: Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>Cross‐regulation of complex biochemical reaction networks is an essential feature of living systems. In a biomimetic spirit, we report on our efforts to program the temporal activation of an artificial metalloenzyme via cross‐regulation by a natural enzyme. In the presence of urea, urease slowly releases ammonia that reversibly inhibits an artificial transfer hydrogenase. Addition of an acid, which acts as fuel, allows to maintain the system out of equilibrium.</jats:p>