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- Matthias Rottmann
- Swiss Tropical and Public Health Institute, Parasite Chemotherapy, CH-4002 Basel, Switzerland.
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- Case McNamara
- Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
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- Bryan K. S. Yeung
- Novartis Institute for Tropical Diseases, 138670 Singapore.
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- Marcus C. S. Lee
- Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
-
- Bin Zou
- Novartis Institute for Tropical Diseases, 138670 Singapore.
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- Bruce Russell
- Laboratory of Malaria Immunobiology, Singapore Immunology Network, Agency for Science Technology and Research (A*STAR), Biopolis, 138648, Singapore.
-
- Patrick Seitz
- Swiss Tropical and Public Health Institute, Parasite Chemotherapy, CH-4002 Basel, Switzerland.
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- David M. Plouffe
- Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
-
- Neekesh V. Dharia
- Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
-
- Jocelyn Tan
- Novartis Institute for Tropical Diseases, 138670 Singapore.
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- Steven B. Cohen
- Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
-
- Kathryn R. Spencer
- Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
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- Gonzalo E. González-Páez
- Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
-
- Suresh B. Lakshminarayana
- Novartis Institute for Tropical Diseases, 138670 Singapore.
-
- Anne Goh
- Novartis Institute for Tropical Diseases, 138670 Singapore.
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- Rossarin Suwanarusk
- Laboratory of Malaria Immunobiology, Singapore Immunology Network, Agency for Science Technology and Research (A*STAR), Biopolis, 138648, Singapore.
-
- Timothy Jegla
- Department of Biology and Huck Institute of Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.
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- Esther K. Schmitt
- Natural Products Unit, Novartis Pharma AG, CH-4002 Basel, Switzerland.
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- Hans-Peter Beck
- Swiss Tropical and Public Health Institute, Parasite Chemotherapy, CH-4002 Basel, Switzerland.
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- Reto Brun
- Swiss Tropical and Public Health Institute, Parasite Chemotherapy, CH-4002 Basel, Switzerland.
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- Francois Nosten
- Shoklo Malaria Research Unit, Mae Sot, Tak 63110, Thailand.
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- Laurent Renia
- Laboratory of Malaria Immunobiology, Singapore Immunology Network, Agency for Science Technology and Research (A*STAR), Biopolis, 138648, Singapore.
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- Veronique Dartois
- Novartis Institute for Tropical Diseases, 138670 Singapore.
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- Thomas H. Keller
- Novartis Institute for Tropical Diseases, 138670 Singapore.
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- David A. Fidock
- Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.
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- Elizabeth A. Winzeler
- Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.
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- Thierry T. Diagana
- Novartis Institute for Tropical Diseases, 138670 Singapore.
書誌事項
- 公開日
- 2010-09-03
- DOI
-
- 10.1126/science.1193225
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:title>Antimalarial Drug Candidate</jats:title> <jats:p> Spiroindolones were discovered as promising antimalarial drug candidates through a high-throughput screening approach that should be applicable to a range of neglected infectious diseases. <jats:bold> Rottmann <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="1175" related-article-type="in-this-issue" vol="329" xlink:href="10.1126/science.1193225">1175</jats:related-article> ; see the Perspective by <jats:bold> <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="5996" page="1153" related-article-type="in-this-issue" vol="329" xlink:href="10.1126/science.1194923">Wells</jats:related-article> </jats:bold> ) present the preclinical profile for an optimized spiroindolone drug candidate, NITD609. They obtained evidence for a decrease in drug sensitivity in strains of the malaria parasite <jats:italic>Plasmodium falciparum</jats:italic> bearing amino acid mutations in the P-type ATPase, indicating possible mechanisms of action and/or resistance. </jats:p>
収録刊行物
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- Science
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Science 329 (5996), 1175-1180, 2010-09-03
American Association for the Advancement of Science (AAAS)