Hairpin conformation of amphidinols possibly accounting for potent membrane permeabilizing activities
書誌事項
- 公開日
- 2005-03
- 権利情報
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- https://www.elsevier.com/tdm/userlicense/1.0/
- DOI
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- 10.1016/j.tet.2005.01.069
- 公開者
- Elsevier BV
この論文をさがす
説明
Amphidinols are a unique dinoflagellate metabolite with potent antifungal activity. We examined membrane permeabilizing action by amphidinol analogues with structural variations in polyhydroxy and polyene moieties. Consequently, the polyene and polyhydroxy moieties turned out to play important roles in binding to lipid bilayer membrane and in forming ion-permeable pore/lesion across membrane, respectively. NMR-constrained modeling experiments have revealed for the fist time that amphidinols in membrane generally take a hairpin configuration, which plausibly accounts for their potent antifungal and other membrane permeabilizing activities.
収録刊行物
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- Tetrahedron
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Tetrahedron 61 (11), 2795-2802, 2005-03
Elsevier BV