NAD <sup>+</sup> repletion improves muscle function in muscular dystrophy and counters global PARylation
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- Dongryeol Ryu
- Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
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- Hongbo Zhang
- Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
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- Eduardo R. Ropelle
- Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
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- Vincenzo Sorrentino
- Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
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- Davi A. G. Mázala
- Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD 20742, USA.
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- Laurent Mouchiroud
- Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
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- Philip L. Marshall
- Interdisciplinary School of Health Sciences, University of Ottawa Brain and Mind Research Institute and Centre for Neuromuscular Disease, Ottawa, Ontario K1H 8M5, Canada.
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- Matthew D. Campbell
- Department of Radiology, University of Washington, Seattle, WA 98195, USA.
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- Amir Safi Ali
- Department of Radiology, University of Washington, Seattle, WA 98195, USA.
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- Gary M. Knowels
- Department of Radiology, University of Washington, Seattle, WA 98195, USA.
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- Stéphanie Bellemin
- Centre de Génétique et de Physiologie Moléculaires et Cellulaires, Université Claude Bernard Lyon 1, CNRS UMR 5534, 69622 Villeurbanne, France.
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- Shama R. Iyer
- Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
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- Xu Wang
- Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
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- Karim Gariani
- Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
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- Anthony A. Sauve
- Department of Pharmacology, Weill Cornell Medical School, New York, NY 10065, USA.
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- Carles Cantó
- Nestlé Institute of Health Sciences, 1015 Lausanne, Switzerland.
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- Kevin E. Conley
- Department of Radiology, University of Washington, Seattle, WA 98195, USA.
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- Ludivine Walter
- Centre de Génétique et de Physiologie Moléculaires et Cellulaires, Université Claude Bernard Lyon 1, CNRS UMR 5534, 69622 Villeurbanne, France.
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- Richard M. Lovering
- Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
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- Eva R. Chin
- Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD 20742, USA.
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- Bernard J. Jasmin
- Department of Cellular and Molecular Medicine and Centre for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
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- David J. Marcinek
- Department of Radiology, University of Washington, Seattle, WA 98195, USA.
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- Keir J. Menzies
- Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
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- Johan Auwerx
- Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
説明
<jats:p> NAD <jats:sup>+</jats:sup> treatment can reverse the functional decline in degenerating muscles. </jats:p>
収録刊行物
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- Science Translational Medicine
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Science Translational Medicine 8 (361), 2016-10-19
American Association for the Advancement of Science (AAAS)
