Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Lian-Jiu Su, Jia-Hao Zhang, Hernando Gomez, Raghavan Murugan, Xing Hong, Dongxue Xu, Fan Jiang, Zhi-Yong Peng

doi:10.1155/2019/5080843

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

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Lian-Jiu Su

Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071 Hubei Province, China
Jia-Hao Zhang

Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071 Hubei Province, China
Hernando Gomez

Center of Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, 15223 PA, USA
Raghavan Murugan

Center of Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, 15223 PA, USA
Xing Hong

Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071 Hubei Province, China
Dongxue Xu

Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071 Hubei Province, China
Fan Jiang

Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071 Hubei Province, China
Zhi-Yong Peng

Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071 Hubei Province, China

書誌事項

公開日: 2019-10-13

権利情報

http://creativecommons.org/licenses/by/4.0/

DOI

10.1155/2019/5080843

公開者: Wiley

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説明

<jats:p>Reactive oxygen species- (ROS-) induced lipid peroxidation plays a critical role in cell death including apoptosis, autophagy, and ferroptosis. This fundamental and conserved mechanism is based on an excess of ROS which attacks biomembranes, propagates lipid peroxidation chain reactions, and subsequently induces different types of cell death. A highly evolved sophisticated antioxidant system exists that acts to protect the cells from oxidative damage. In this review, we discussed how ROS propagate lipid peroxidation chain reactions and how the products of lipid peroxidation initiate apoptosis and autophagy in current models. We also discussed the mechanism of lipid peroxidation during ferroptosis, and we summarized lipid peroxidation in pathological conditions of critical illness. We aim to bring a more global and integrative sight to know how different ROS-induced lipid peroxidation occurs among apoptosis, autophagy, and ferroptosis.</jats:p>