CD8 <sup>+</sup> T Cell Cross-Priming via Transfer of Proteasome Substrates

DOI Web Site 被引用文献7件
  • Christopher C. Norbury
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892–0440, USA.
  • Sameh Basta
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892–0440, USA.
  • Keri B. Donohue
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892–0440, USA.
  • David C. Tscharke
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892–0440, USA.
  • Michael F. Princiotta
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892–0440, USA.
  • Peter Berglund
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892–0440, USA.
  • James Gibbs
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892–0440, USA.
  • Jack R. Bennink
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892–0440, USA.
  • Jonathan W. Yewdell
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD, 20892–0440, USA.

書誌事項

公開日
2004-05-28
DOI
  • 10.1126/science.1096378
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p> “Cross-priming” describes the activation of naïve CD8 <jats:sup>+</jats:sup> T cells by professional antigen-presenting cells that have acquired viral or tumor antigens from “donor” cells. Antigen transfer is believed to be mediated by donor cell–derived molecular chaperones bearing short peptide ligands generated by proteasome degradation of protein antigens. We show here that cross-priming is based on the transfer of proteasome substrates rather than peptides. These findings are potentially important for the rational design of vaccines that elicit CD8 <jats:sup>+</jats:sup> T cell responses. </jats:p>

収録刊行物

  • Science

    Science 304 (5675), 1318-1321, 2004-05-28

    American Association for the Advancement of Science (AAAS)

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