Synthesis of analogues of GABA. VI. Stereoisomers of <i>cis</i> -3-Aminocyclohexanecarboxylic acid
書誌事項
- 公開日
- 1981-10-01
- 権利情報
-
- https://doi.org/10.1071/journalslicense
- DOI
-
- 10.1071/ch9812231
- 公開者
- CSIRO Publishing
この論文をさがす
説明
<jats:p>The syntheses are described of (1 R ,3 S )- and (1 S ,3 R )-3-aminocyclohexanecarboxylic acids via unsaturated intermediates suitable for tritium labelling. The absolute stereochemistry was determined by an alternative synthesis of the (1 R ,3 S ) isomer from (R)-3-oxocyclohexanecarboxylic acid. The (1 S ,3 R ) isomer showed a similar potency to GABA as an inhibitor of the uptake of radioactive GABA by rat brain slices whereas the (1 R ,3 S ) isomer was at least 20 times less potent.</jats:p>
収録刊行物
-
- Australian Journal of Chemistry
-
Australian Journal of Chemistry 34 (10), 2231-2236, 1981-10-01
CSIRO Publishing
