Physical activity, fitness and cardiovascular disease risk in adults: interactions with insulin resistance and obesity
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- Jason M. R. Gill
- Institute of Diet, Exercise and Lifestyle (IDEAL), Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, U.K.
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- Dalia Malkova
- Institute of Diet, Exercise and Lifestyle (IDEAL), Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, U.K.
書誌事項
- 公開日
- 2006-03-15
- DOI
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- 10.1042/cs20050207
- 公開者
- Portland Press Ltd.
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説明
<jats:p>There is a considerable body of evidence gathered from studies over the past half a century indicating that a high level of physical activity and a moderately high or high degree of cardiorespiratory fitness reduces the risk of CVD (cardiovascular disease). Recent data suggest that high levels of physical activity or fitness may be particularly beneficial to individuals with insulin-resistant conditions, such as the metabolic syndrome, Type II diabetes or obesity. These individuals, if unfit and sedentary, exhibit increased CVD risk, but their dose–response relationship for physical activity/fitness appears to be particularly steep such that, when they undertake high levels of activity (or have high fitness), their level of risk becomes closer to that of their normal weight or nondiabetic peers. This may be due to effects of physical activity in normalizing the metabolic dysfunction particularly associated with insulin-resistant conditions.</jats:p>
収録刊行物
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- Clinical Science
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Clinical Science 110 (4), 409-425, 2006-03-15
Portland Press Ltd.
