Mineralocorticoid Action: Target Tissue Specificity Is Enzyme, Not Receptor, Mediated

DOI Web Site 被引用文献50件
  • John W. Funder
    Medical Research Centre, Prince Henry's Hospital, Melbourne, Australia 3004.
  • Paul T. Pearce
    Medical Research Centre, Prince Henry's Hospital, Melbourne, Australia 3004.
  • Robin Smith
    Medical Research Centre, Prince Henry's Hospital, Melbourne, Australia 3004.
  • A. Ian Smith
    Medical Research Centre, Prince Henry's Hospital, Melbourne, Australia 3004.

書誌事項

公開日
1988-10-28
DOI
  • 10.1126/science.2845584
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p>Mineralocorticoid receptors, both when in tissue extracts and when recombinant-derived, have equal affinity for the physiological mineralocorticoid aldosterone and for the glucocorticoids cortisol and corticosterone, which circulate at much higher concentrations than aldosterone. Such receptors are found in physiological mineralocorticoid target tissues (kidney, parotid, and colon) and in nontarget tissues such as hippocampus and heart. In mineralocorticoid target tissues the receptors are selective for aldosterone in vivo because of the presence of the enzyme 11 β-hydroxy-steroid dehydrogenase, which converts cortisol and corticosterone, but not aldosterone, to their 11-keto analogs. These analogs cannot bind to mineralocorticoid receptors.</jats:p>

収録刊行物

  • Science

    Science 242 (4878), 583-585, 1988-10-28

    American Association for the Advancement of Science (AAAS)

被引用文献 (50)*注記

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