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- Kara A. Bernstein
- Columbia University Medical Center, Department of Genetics & Development, New York, New York 10032;,
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- Serge Gangloff
- CEA, DSV, iRCM, SIGRR, LERA, Fontenay-aux-Roses F-92265, France;
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- Rodney Rothstein
- Columbia University Medical Center, Department of Genetics & Development, New York, New York 10032;,
抄録
<jats:p>The RecQ helicases are conserved from bacteria to humans and play a critical role in genome stability. In humans, loss of RecQ gene function is associated with cancer predisposition and/or premature aging. Recent experiments have shown that the RecQ helicases function during distinct steps during DNA repair; DNA end resection, displacement-loop (D-loop) processing, branch migration, and resolution of double Holliday junctions (dHJs). RecQ function in these different processing steps has important implications for its role in repair of double-strand breaks (DSBs) that occur during DNA replication and meiosis, as well as at specific genomic loci such as telomeres.</jats:p>
収録刊行物
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- Annual Review of Genetics
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Annual Review of Genetics 44 (1), 393-417, 2010-12-01
Annual Reviews