Hazara virus infection is lethal for adult type I interferon receptor-knockout mice and may act as a surrogate for infection with the human-pathogenic Crimean–Congo hemorrhagic fever virus

Stuart D. Dowall, Stephen Findlay-Wilson, Emma Rayner, Geoff Pearson, Janice Pickersgill, Antony Rule, Natasha Merredew, Hazel Smith, John Chamberlain, Roger Hewson

doi:10.1099/vir.0.038455-0

Hazara virus infection is lethal for adult type I interferon receptor-knockout mice and may act as a surrogate for infection with the human-pathogenic Crimean–Congo hemorrhagic fever virus

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Stuart D. Dowall

Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK
Stephen Findlay-Wilson

Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK
Emma Rayner

Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK
Geoff Pearson

Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK
Janice Pickersgill

Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK
Antony Rule

Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK
Natasha Merredew

Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK
Hazel Smith

Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK
John Chamberlain

Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK
Roger Hewson

Health Protection Agency, Porton Down, Salisbury, Wiltshire SP4 0JG, UK

書誌事項

公開日: 2012-03-01

DOI

10.1099/vir.0.038455-0

公開者: Microbiology Society

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説明

<jats:p>Hazara virus (HAZV) is closely related to the Crimean–Congo hemorrhagic fever virus (CCHFV). HAZV has not been reported to cause human disease; work with infectious material can be carried out at containment level (CL)-2. By contrast, CCHFV causes a haemorrhagic fever in humans and requires CL-4 facilities. A disease model of HAZV infection in mice deficient in the type I interferon receptor is reported in this study. Dose–response effects were seen with higher doses, resulting in a shorter time to death and earlier detection of viral loads in organs. The lowest dose of 10 p.f.u. was still lethal in over 50 % of the mice. Histopathological findings were identified in the liver, spleen and lymph nodes, with changes similar to a recent mouse model of CCHFV infection. The findings demonstrate that inoculation of mice with HAZV may act as a useful surrogate model for the testing of antiviral agents against CCHFV.</jats:p>