Stress-Induced Analgesia in Humans: Endogenous Opioids and Naloxone-Reversible Depression of Pain Reflexes
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- Jean Claude Willer
- Laboratoire de Physiologie, Faculté de Médecine Saint-Antoine, 27 Rue Chaligny F75571 Paris Cedex 12, France
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- Henri Dehen
- Clinique Neurologique, Hôpital Beaujon, 92110 Clichy, France
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- Jean Cambier
- Clinique Neurologique, Hôpital Beaujon, 92110 Clichy, France
書誌事項
- 公開日
- 1981-05-08
- DOI
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- 10.1126/science.6261330
- 公開者
- American Association for the Advancement of Science (AAAS)
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説明
<jats:p>The cumulative effects of a repetitive stress induced by anticipation of pain (noxious foot shock) were studied on the threshold of a nociceptive flexion reflex of the lower limb. The threshold of the nociceptive reflex progressively increased with the repetition of the stress. This effect was reversed by naloxone, which even produced hyperalgesia, since a rapid and significant decrease in this threshold, below the initial values, was noted. The data provide evidence for involvement of endogenous opioids in the phenomenon of stress-induced analgesia in normal man.</jats:p>
収録刊行物
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- Science
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Science 212 (4495), 689-691, 1981-05-08
American Association for the Advancement of Science (AAAS)
