Functional disorders of the sympathetic nervous system in mice lacking the α <sub>1B</sub> subunit (Ca <sub>v</sub> 2.2) of N-type calcium channels

DOI Web Site PubMed 被引用文献17件 オープンアクセス
  • Mitsuhiro Ino
    Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860, Japan; and Institute of Molecular Pharmacology and Biophysics, University of Cincinnati, College of Medicine,...
  • Takashi Yoshinaga
    Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860, Japan; and Institute of Molecular Pharmacology and Biophysics, University of Cincinnati, College of Medicine,...
  • Minoru Wakamori
    Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860, Japan; and Institute of Molecular Pharmacology and Biophysics, University of Cincinnati, College of Medicine,...
  • Norimasa Miyamoto
    Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860, Japan; and Institute of Molecular Pharmacology and Biophysics, University of Cincinnati, College of Medicine,...
  • Eiki Takahashi
    Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860, Japan; and Institute of Molecular Pharmacology and Biophysics, University of Cincinnati, College of Medicine,...
  • Jiro Sonoda
    Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860, Japan; and Institute of Molecular Pharmacology and Biophysics, University of Cincinnati, College of Medicine,...
  • Takaki Kagaya
    Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860, Japan; and Institute of Molecular Pharmacology and Biophysics, University of Cincinnati, College of Medicine,...
  • Tohru Oki
    Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860, Japan; and Institute of Molecular Pharmacology and Biophysics, University of Cincinnati, College of Medicine,...
  • Takeshi Nagasu
    Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860, Japan; and Institute of Molecular Pharmacology and Biophysics, University of Cincinnati, College of Medicine,...
  • Yukio Nishizawa
    Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860, Japan; and Institute of Molecular Pharmacology and Biophysics, University of Cincinnati, College of Medicine,...
  • Isao Tanaka
    Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860, Japan; and Institute of Molecular Pharmacology and Biophysics, University of Cincinnati, College of Medicine,...
  • Keiji Imoto
    Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860, Japan; and Institute of Molecular Pharmacology and Biophysics, University of Cincinnati, College of Medicine,...
  • Shinichi Aizawa
    Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860, Japan; and Institute of Molecular Pharmacology and Biophysics, University of Cincinnati, College of Medicine,...
  • Sheryl Koch
    Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860, Japan; and Institute of Molecular Pharmacology and Biophysics, University of Cincinnati, College of Medicine,...
  • Arnold Schwartz
    Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860, Japan; and Institute of Molecular Pharmacology and Biophysics, University of Cincinnati, College of Medicine,...
  • Tetsuhiro Niidome
    Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860, Japan; and Institute of Molecular Pharmacology and Biophysics, University of Cincinnati, College of Medicine,...
  • Kohei Sawada
    Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860, Japan; and Institute of Molecular Pharmacology and Biophysics, University of Cincinnati, College of Medicine,...
  • Yasuo Mori
    Tsukuba Research Laboratories, Eisai Co., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan; Department of Information Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto University School of Medicine, 2-2-1, Honjo, Kumamoto 860, Japan; and Institute of Molecular Pharmacology and Biophysics, University of Cincinnati, College of Medicine,...

書誌事項

公開日
2001-04-10
DOI
  • 10.1073/pnas.081089398
公開者
Proceedings of the National Academy of Sciences

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説明

<jats:p> N-type voltage-dependent Ca <jats:sup>2+</jats:sup> channels (VDCCs), predominantly localized in the nervous system, have been considered to play an essential role in a variety of neuronal functions, including neurotransmitter release at sympathetic nerve terminals. As a direct approach to elucidating the physiological significance of N-type VDCCs, we have generated mice genetically deficient in the α <jats:sub>1B</jats:sub> subunit (Ca <jats:sub>v</jats:sub> 2.2). The α <jats:sub>1B</jats:sub> -deficient null mice, surprisingly, have a normal life span and are free from apparent behavioral defects. A complete and selective elimination of N-type currents, sensitive to ω-conotoxin GVIA, was observed without significant changes in the activity of other VDCC types in neuronal preparations of mutant mice. The baroreflex response, mediated by the sympathetic nervous system, was markedly reduced after bilateral carotid occlusion. In isolated left atria prepared from N-type-deficient mice, the positive inotropic responses to electrical sympathetic neuronal stimulation were dramatically decreased compared with those of normal mice. In contrast, parasympathetic nervous activity in the mutant mice was nearly identical to that of wild-type mice. Interestingly, the mutant mice showed sustained elevation of heart rate and blood pressure. These results provide direct evidence that N-type VDCCs are indispensable for the function of the sympathetic nervous system in circulatory regulation and indicate that N-type VDCC-deficient mice will be a useful model for studying disorders attributable to sympathetic nerve dysfunction. </jats:p>

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