Inflammation in myocardial disease: From myocarditis to dilated cardiomyopathy
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- Kyoko Imanaka‐Yoshida
- Department of Pathology and Matrix Biology Mie University Graduate School of Medicine Mie Japan
書誌事項
- 公開日
- 2019-11-05
- 資源種別
- journal article
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/pin.12868
- 公開者
- Wiley
この論文をさがす
説明
<jats:p>Dilated cardiomyopathy (DCM) is a heterogeneous group of myocardial diseases clinically defined by the presence of left ventricular dilatation and contractile dysfunction. Among various causes of DCM, a progression from viral myocarditis to DCM has long been hypothesized. Supporting this possibility, studies by endomyocardial biopsy, the only method to obtain a definite diagnosis of myocarditis at present, have provided evidence of inflammation in the myocardium in DCM patients. A number of experimental studies have elucidated a cell‐mediated autoimmune mechanism triggered by viral infection in the progression of myocarditis to DCM. In addition, the important role of inflammation in the pathogenesis of heart failure has been recognized, and many terms including myocarditis, inflammatory cardiomyopathy, and inflammatory DCM have been used for myocardial diseases associated with inflammation. This review discusses the pathophysiology of inflammation in the myocardium, and refers to diagnosis and treatment based on these concepts.</jats:p>
収録刊行物
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- Pathology International
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Pathology International 70 (1), 1-11, 2019-11-05
Wiley