Early-life stress has persistent effects on amygdala function and development in mice and humans
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- Matthew Malter Cohen
- Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, New York, NY 10065;
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- Deqiang Jing
- Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065; and
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- Rui R. Yang
- Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065; and
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- Nim Tottenham
- Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, New York, NY 10065;
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- Francis S. Lee
- Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065; and
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- B. J. Casey
- Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, New York, NY 10065;
説明
<jats:title>Significance</jats:title> <jats:p>The current study provides evidence of early and persistent alterations in anxious behavior and amygdala function following the early-life stress of disorganized parental care. These changes in both brain and behavior are not diminished when the stressor is removed nor diminished with the development of prefrontal regulatory regions. The findings underscore the importance of early-life experiences on later development and highlight the need for early intervention for populations at-risk following early-life stressors.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 110 (45), 18274-18278, 2013-10-21
Proceedings of the National Academy of Sciences