Coronary microvascular dysfunction in diabetes mellitus

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  • Aleksandar Kibel
    Department for Heart and Vascular Diseases, Clinic of Internal Medicine, Osijek University Hospital, Osijek, Croatia
  • Kristina Selthofer-Relatic
    Department for Heart and Vascular Diseases, Clinic of Internal Medicine, Osijek University Hospital, Osijek, Croatia
  • Ines Drenjancevic
    Department of Physiology and Immunology, Faculty of Medicine, University of Osijek, Croatia
  • Tatjana Bacun
    Department of Internal Medicine, Faculty of Medicine, University of Osijek, Osijek, Croatia
  • Ivica Bosnjak
    Department for Heart and Vascular Diseases, Clinic of Internal Medicine, Osijek University Hospital, Osijek, Croatia
  • Dijana Kibel
    Department of Physiology and Immunology, Faculty of Medicine, University of Osijek, Croatia
  • Mario Gros
    Department of Physiology and Immunology, Faculty of Medicine, University of Osijek, Croatia

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<jats:p> The significance, mechanisms and consequences of coronary microvascular dysfunction associated with diabetes mellitus are topics into which we have insufficient insight at this time. It is widely recognized that endothelial dysfunction that is caused by diabetes in various vascular beds contributes to a wide range of complications and exerts unfavorable effects on microcirculatory regulation. The coronary microcirculation is precisely regulated through a number of interconnected physiological processes with the purpose of matching local blood flow to myocardial metabolic demands. Dysregulation of this network might contribute to varying degrees of pathological consequences. This review discusses the most important findings regarding coronary microvascular dysfunction in diabetes from pre-clinical and clinical perspectives. </jats:p>

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