Direct Dehydroxytrifluoromethylthiolation of Alcohols Using Silver(I) Trifluoromethanethiolate and Tetra‐<i>n</i>‐butylammonium Iodide

Jian‐Bo Liu, Xiu‐Hua Xu, Zeng‐Hao Chen, Feng‐Ling Qing

doi:10.1002/anie.201409983

Direct Dehydroxytrifluoromethylthiolation of Alcohols Using Silver(I) Trifluoromethanethiolate and Tetra‐<i>n</i>‐butylammonium Iodide

DOI Web Site Web Site 被引用文献2件

書誌事項

公開日: 2014-11-24

権利情報

http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1002/anie.201409983

公開者: Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>An unprecedented reaction for the direct trifluoromethylthiolation and fluorination of alkyl alcohols using AgSCF<jats:sub>3</jats:sub> and nBu<jats:sub>4</jats:sub>NI has been developed. The trifluoromethylthiolated compounds and alkyl fluorides were selectively formed by changing the ratio of AgSCF<jats:sub>3</jats:sub>/nBu<jats:sub>4</jats:sub>NI. This protocol is tolerant of different functional groups and might be applicable to late‐stage trifluoromethylthiolation of alcohols.</jats:p>