Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice

DOI Web Site 被引用文献2件
  • I Ofek
    Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, Israel.
  • S Cohen
    Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, Israel.
  • R Rahmani
    Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, Israel.
  • K Kabha
    Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, Israel.
  • D Tamarkin
    Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, Israel.
  • Y Herzig
    Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, Israel.
  • E Rubinstein
    Department of Human Microbiology, Sackler Faculty of Medicine, Tel Aviv University, Israel.

書誌事項

公開日
1994-02
権利情報
  • https://journals.asm.org/non-commercial-tdm-license
DOI
  • 10.1128/aac.38.2.374
公開者
American Society for Microbiology

この論文をさがす

説明

<jats:p>Polymyxin B nonapeptide, derived by cleavage of the fatty acyl diaminobutyric acid from polymyxin B, is considerably less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes. The peptide rendered all 53 polymyxin-susceptible strains tested more susceptible to novobiocin, lowering the MIC of novobiocin eightfold or more. The combination of polymyxin B nonapeptide with novobiocin or with erythromycin administered intraperitoneally in multiple doses synergistically protected mice infected with gram-negative bacteria. This combination may be clinically useful because of the apparent rarity of the acquisition of resistance.</jats:p>

収録刊行物

被引用文献 (2)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ