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- Lale Ozcan
- Departments of 1Medicine,
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- Ira Tabas
- Departments of 1Medicine,
書誌事項
- 公開日
- 2012-02-18
- DOI
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- 10.1146/annurev-med-043010-144749
- 公開者
- Annual Reviews
この論文をさがす
説明
<jats:p> Perturbations in the normal functions of the endoplasmic reticulum (ER) trigger a signaling network that coordinates adaptive and apoptotic responses. There is accumulating evidence implicating prolonged ER stress in the development and progression of many diseases, including neurodegeneration, atherosclerosis, type 2 diabetes, liver disease, and cancer. With the improved understanding of the underlying molecular mechanisms, therapeutic interventions that target the ER stress response would be potential strategies to treat various diseases driven by prolonged ER stress. </jats:p>
収録刊行物
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- Annual Review of Medicine
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Annual Review of Medicine 63 (1), 317-328, 2012-02-18
Annual Reviews
