Chemistry for Positron Emission Tomography: Recent Advances in <sup>11</sup>C‐, <sup>18</sup>F‐, <sup>13</sup>N‐, and <sup>15</sup>O‐Labeling Reactions
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- Xiaoyun Deng
- Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital & Department of Radiology Harvard Medical School Boston MA 02114 USA
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- Jian Rong
- Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital & Department of Radiology Harvard Medical School Boston MA 02114 USA
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- Lu Wang
- Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital & Department of Radiology Harvard Medical School Boston MA 02114 USA
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- Neil Vasdev
- Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital & Department of Radiology Harvard Medical School Boston MA 02114 USA
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- Lei Zhang
- Medicine Design Pfizer Inc. Cambridge MA 02139 USA
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- Lee Josephson
- Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital & Department of Radiology Harvard Medical School Boston MA 02114 USA
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- Steven H. Liang
- Division of Nuclear Medicine and Molecular Imaging Massachusetts General Hospital & Department of Radiology Harvard Medical School Boston MA 02114 USA
書誌事項
- 公開日
- 2019-01-14
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/anie.201805501
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>Positron emission tomography (PET) is a molecular imaging technology that provides quantitative information about function and metabolism in biological processes in vivo for disease diagnosis and therapy assessment. The broad application and rapid advances of PET has led to an increased demand for new radiochemical methods to synthesize highly specific molecules bearing positron‐emitting radionuclides. This Review provides an overview of commonly used labeling reactions through examples of clinically relevant PET tracers and highlights the most recent developments and breakthroughs over the past decade, with a focus on <jats:sup>11</jats:sup>C, <jats:sup>18</jats:sup>F, <jats:sup>13</jats:sup>N, and <jats:sup>15</jats:sup>O.</jats:p>
収録刊行物
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- Angewandte Chemie International Edition
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Angewandte Chemie International Edition 58 (9), 2580-2605, 2019-01-14
Wiley
