Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase
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- Shigeaki Kato
- S. Kato, Y. Masuhiro, T. Kitamoto, S. Uchiyama, H. Sasaki, S. Masushige, Department of Agricultural Chemistry, Tokyo University of Agriculture, Setagayaku, Tokyo 156, Japan.
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- Hideki Endoh
- H. Endoh and H. Kawashima, Molecular Medicine Research Laboratory II, Yamanouchi Institute for Drug Discovery Research Co. Ltd., Tsukuba, Ibaraki 305, Japan.
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- Yoshikazu Masuhiro
- S. Kato, Y. Masuhiro, T. Kitamoto, S. Uchiyama, H. Sasaki, S. Masushige, Department of Agricultural Chemistry, Tokyo University of Agriculture, Setagayaku, Tokyo 156, Japan.
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- Takuya Kitamoto
- S. Kato, Y. Masuhiro, T. Kitamoto, S. Uchiyama, H. Sasaki, S. Masushige, Department of Agricultural Chemistry, Tokyo University of Agriculture, Setagayaku, Tokyo 156, Japan.
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- Shimami Uchiyama
- S. Kato, Y. Masuhiro, T. Kitamoto, S. Uchiyama, H. Sasaki, S. Masushige, Department of Agricultural Chemistry, Tokyo University of Agriculture, Setagayaku, Tokyo 156, Japan.
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- Haruna Sasaki
- S. Kato, Y. Masuhiro, T. Kitamoto, S. Uchiyama, H. Sasaki, S. Masushige, Department of Agricultural Chemistry, Tokyo University of Agriculture, Setagayaku, Tokyo 156, Japan.
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- Shoichi Masushige
- S. Kato, Y. Masuhiro, T. Kitamoto, S. Uchiyama, H. Sasaki, S. Masushige, Department of Agricultural Chemistry, Tokyo University of Agriculture, Setagayaku, Tokyo 156, Japan.
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- Yukiko Gotoh
- Y. Gotoh and E. Nishida, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606, Japan.
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- Eisuke Nishida
- Y. Gotoh and E. Nishida, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606, Japan.
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- Hiroyuki Kawashima
- H. Endoh and H. Kawashima, Molecular Medicine Research Laboratory II, Yamanouchi Institute for Drug Discovery Research Co. Ltd., Tsukuba, Ibaraki 305, Japan.
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- Daniel Metzger
- D. Metzger and P. Chambon, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique (CNRS)/Institut National de la Santé et de la Recherche Médicale (INSERM)/Université Louis Pasteur/Collège de France, BP163-67404 Illkirch Cedex, Communauté Urbaine de Strasbourg, France.
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- Pierre Chambon
- D. Metzger and P. Chambon, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique (CNRS)/Institut National de la Santé et de la Recherche Médicale (INSERM)/Université Louis Pasteur/Collège de France, BP163-67404 Illkirch Cedex, Communauté Urbaine de Strasbourg, France.
書誌事項
- 公開日
- 1995-12
- DOI
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- 10.1126/science.270.5241.1491
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:p> The phosphorylation of the human estrogen receptor (ER) serine residue at position 118 is required for full activity of the ER activation function 1 (AF-1). This Ser <jats:sup>118</jats:sup> is phosphorylated by mitogen-activated protein kinase (MAPK) in vitro and in cells treated with epidermal growth factor (EGF) and insulin-like growth factor (IGF) in vivo. Overexpression of MAPK kinase (MAPKK) or of the guanine nucleotide binding protein Ras, both of which activate MAPK, enhanced estrogen-induced and antiestrogen (tamoxifen)-induced transcriptional activity of wild-type ER, but not that of a mutant ER with an alanine in place of Ser <jats:sup>118</jats:sup> . Thus, the activity of the amino-terminal AF-1 of the ER is modulated by the phosphorylation of Ser <jats:sup>118</jats:sup> through the Ras-MAPK cascade of the growth factor signaling pathways. </jats:p>
収録刊行物
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- Science
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Science 270 (5241), 1491-1494, 1995-12
American Association for the Advancement of Science (AAAS)
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キーワード
- Transcriptional Activation
- Polyunsaturated Alkamides
- Recombinant Fusion Proteins
- Molecular Sequence Data
- Protein Serine-Threonine Kinases
- Transfection
- Cell Line
- Proto-Oncogene Proteins p21(ras)
- Somatomedins
- Proto-Oncogene Proteins
- Serine
- Animals
- Humans
- [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
- Amino Acid Sequence
- Phosphorylation
- Mitogen-Activated Protein Kinase Kinases
- Epidermal Growth Factor
- Estradiol
- Estrogen Antagonists
- Enzyme Activation
- Proto-Oncogene Proteins c-raf
- Tamoxifen
- Receptors, Estrogen
- Calcium-Calmodulin-Dependent Protein Kinases
- Mutation
- Protein Kinases
詳細情報 詳細情報について
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- CRID
- 1361699994557228544
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- NII論文ID
- 80008680862
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- ISSN
- 10959203
- 00368075
- http://id.crossref.org/issn/01934511
- https://id.crossref.org/issn/00368075
- http://id.crossref.org/issn/00368075
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- PubMed
- 7491495
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- データソース種別
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- Crossref
- CiNii Articles
- OpenAIRE
