Matrix Metalloproteinase-9: Many Shades of Function in Cardiovascular Disease
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- Andriy Yabluchanskiy
- San Antonio Cardiovascular Proteomics Center, San Antonio, Texas;
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- Yonggang Ma
- San Antonio Cardiovascular Proteomics Center, San Antonio, Texas;
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- Rugmani Padmanabhan Iyer
- San Antonio Cardiovascular Proteomics Center, San Antonio, Texas;
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- Michael E. Hall
- San Antonio Cardiovascular Proteomics Center, San Antonio, Texas;
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- Merry L. Lindsey
- San Antonio Cardiovascular Proteomics Center, San Antonio, Texas;
Description
<jats:p>Matrix metalloproteinase (MMP)-9, one of the most widely investigated MMPs, regulates pathological remodeling processes that involve inflammation and fibrosis in cardiovascular disease. MMP-9 directly degrades extracellular matrix (ECM) proteins and activates cytokines and chemokines to regulate tissue remodeling. MMP-9 deletion or inhibition has proven overall beneficial in multiple animal models of cardiovascular disease. As such, MMP-9 expression and activity is a common end point measured. MMP-9 cell-specific overexpression, however, has also proven beneficial and highlights the fact that little information is available on the underlying mechanisms of MMP-9 function. In this review, we summarize our current understanding of MMP-9 physiology, including structure, regulation, activation, and downstream effects of increased MMP-9. We discuss MMP-9 roles during inflammation and fibrosis in cardiovascular disease. By concentrating on the substrates of MMP-9 and their roles in cardiovascular disease, we explore the overall function and discuss future directions on the translational potential of MMP-9 based therapies.</jats:p>
Journal
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- Physiology
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Physiology 28 (6), 391-403, 2013-11
American Physiological Society
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Details 詳細情報について
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- CRID
- 1361699994562506496
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- ISSN
- 15489221
- 15489213
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- Data Source
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- Crossref