-
- Andriy Yabluchanskiy
- San Antonio Cardiovascular Proteomics Center, San Antonio, Texas;
-
- Yonggang Ma
- San Antonio Cardiovascular Proteomics Center, San Antonio, Texas;
-
- Rugmani Padmanabhan Iyer
- San Antonio Cardiovascular Proteomics Center, San Antonio, Texas;
-
- Michael E. Hall
- San Antonio Cardiovascular Proteomics Center, San Antonio, Texas;
-
- Merry L. Lindsey
- San Antonio Cardiovascular Proteomics Center, San Antonio, Texas;
説明
<jats:p>Matrix metalloproteinase (MMP)-9, one of the most widely investigated MMPs, regulates pathological remodeling processes that involve inflammation and fibrosis in cardiovascular disease. MMP-9 directly degrades extracellular matrix (ECM) proteins and activates cytokines and chemokines to regulate tissue remodeling. MMP-9 deletion or inhibition has proven overall beneficial in multiple animal models of cardiovascular disease. As such, MMP-9 expression and activity is a common end point measured. MMP-9 cell-specific overexpression, however, has also proven beneficial and highlights the fact that little information is available on the underlying mechanisms of MMP-9 function. In this review, we summarize our current understanding of MMP-9 physiology, including structure, regulation, activation, and downstream effects of increased MMP-9. We discuss MMP-9 roles during inflammation and fibrosis in cardiovascular disease. By concentrating on the substrates of MMP-9 and their roles in cardiovascular disease, we explore the overall function and discuss future directions on the translational potential of MMP-9 based therapies.</jats:p>
収録刊行物
-
- Physiology
-
Physiology 28 (6), 391-403, 2013-11
American Physiological Society