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- Jormay Lim
- Institute of Molecular Cell Biology, A*STAR, 61 Biopolis Drive, 138673, Singapore.
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- Jean Paul Thiery
- Institute of Molecular Cell Biology, A*STAR, 61 Biopolis Drive, 138673, Singapore.
書誌事項
- 公開日
- 2012-10-01
- DOI
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- 10.1242/dev.071209
- 公開者
- The Company of Biologists
この論文をさがす
説明
<jats:p>Epithelial-mesenchymal transition (EMT) is a crucial, evolutionarily conserved process that occurs during development and is essential for shaping embryos. Also implicated in cancer, this morphological transition is executed through multiple mechanisms in different contexts, and studies suggest that the molecular programs governing EMT, albeit still enigmatic, are embedded within developmental programs that regulate specification and differentiation. As we review here, knowledge garnered from studies of EMT during gastrulation, neural crest delamination and heart formation have furthered our understanding of tumor progression and metastasis.</jats:p>
収録刊行物
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- Development
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Development 139 (19), 3471-3486, 2012-10-01
The Company of Biologists
