Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions
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- Ana Martín-Pardillos
- Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands;
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- Anastasia Tsaalbi-Shtylik
- Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands;
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- Si Chen
- Department of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands;
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- Seka Lazare
- European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands;
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- Ronald P. van Os
- European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands;
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- Albertina Dethmers-Ausema
- European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands;
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- Nima Borhan Fakouri
- Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark;
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- Matthias Bosshard
- Department of Molecular Mechanisms of Disease, University of Zürich, Zürich, Switzerland;
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- Rossana Aprigliano
- Department of Molecular Mechanisms of Disease, University of Zürich, Zürich, Switzerland;
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- Barbara van Loon
- Department of Molecular Mechanisms of Disease, University of Zürich, Zürich, Switzerland;
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- Daniela C. F. Salvatori
- Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands; and
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- Keiji Hashimoto
- Department of Pharmacological Sciences, Stony Brook University Medical School, Stony Brook, NY
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- Celia Dingemanse-van der Spek
- Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands;
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- Masaaki Moriya
- Department of Pharmacological Sciences, Stony Brook University Medical School, Stony Brook, NY
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- Lene Juel Rasmussen
- Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark;
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- Gerald de Haan
- European Research Institute for the Biology of Ageing, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands;
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- Marc H. G. P. Raaijmakers
- Department of Hematology, Erasmus Medical Center Cancer Institute, Rotterdam, The Netherlands;
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- Niels de Wind
- Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands;
書誌事項
- 公開日
- 2017-09-28
- DOI
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- 10.1182/blood-2017-01-764274
- 公開者
- American Society of Hematology
この論文をさがす
説明
<jats:title>Key Points</jats:title> <jats:p>Tolerance of oxidative DNA lesions ensures the genomic and functional integrity of hematopoietic stem and precursor cells. Endogenous DNA damage–induced replication stress is associated with mitochondrial dysfunction.</jats:p>
収録刊行物
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- Blood
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Blood 130 (13), 1523-1534, 2017-09-28
American Society of Hematology
