The TIM‐barrel fold: a versatile framework for efficient enzymes
書誌事項
- 公開日
- 2001-03-12
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1016/s0014-5793(01)02236-0
- 公開者
- Wiley
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説明
<jats:p>Recent studies on triosephosphate isomerase (TIM)‐barrel enzymes highlight the remarkable versatility of the TIM‐barrel scaffold. At least 15 distinct enzyme families use this framework to generate the appropriate active site geometry, always at the C‐terminal end of the eight parallel β‐strands of the barrel. Sequence and structure comparisons now suggest that many of the TIM‐barrel enzymes are evolutionarily related. Common structural properties of TIM‐barrel enzymes are discussed.</jats:p>
収録刊行物
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- FEBS Letters
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FEBS Letters 492 (3), 193-198, 2001-03-12
Wiley
