Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees

DOI Web Site 被引用文献10件
  • Kathy L. Moser
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Barbara R. Neas
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Jane E. Salmon
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Hua Yu
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Courtney Gray-McGuire
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Neeraj Asundi
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Gail R. Bruner
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Jerome Fox
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Jennifer Kelly
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Stephanie Henshall
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Debra Bacino
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Myron Dietz
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Robert Hogue
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Gerald Koelsch
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Lydia Nightingale
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Tim Shaver
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Nabih I. Abdou
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Daniel A. Albert
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Craig Carson
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Michelle Petri
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Edward L. Treadwell
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • Judith A. James
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...
  • John B. Harley
    Arthritis and Immunology Program and Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104; Departments of Biostatistics and Epidemiology and Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104; Division of Rheumatic Diseases, Hospital for Special Surgery, New York, NY 10021; Department of Medicine/Rheumatology, University of Chicago, Chicago, IL 60637; McBride Clinic, Edmond, OK 73013; Division of Rheumatology, Johns Hopkins Hospital,...

書誌事項

公開日
1998-12-08
DOI
  • 10.1073/pnas.95.25.14869
公開者
Proceedings of the National Academy of Sciences

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説明

<jats:p> Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by production of autoantibodies against intracellular antigens including DNA, ribosomal P, Ro (SS-A), La (SS-B), and the spliceosome. Etiology is suspected to involve genetic and environmental factors. Evidence of genetic involvement includes: associations with HLA-DR3, HLA-DR2, Fcγ receptors (FcγR) IIA and IIIA, and hereditary complement component deficiencies, as well as familial aggregation, monozygotic twin concordance >20%, λ <jats:sub>s</jats:sub> > 10, purported linkage at 1q41–42, and inbred mouse strains that consistently develop lupus. We have completed a genome scan in 94 extended multiplex pedigrees by using model-based linkage analysis. Potential [log <jats:sub>10</jats:sub> of the odds for linkage (lod) > 2.0] SLE loci have been identified at chromosomes 1q41, 1q23, and 11q14–23 in African-Americans; 14q11, 4p15, 11q25, 2q32, 19q13, 6q26–27, and 12p12–11 in European-Americans; and 1q23, 13q32, 20q13, and 1q31 in all pedigrees combined. An effect for the FcγRIIA candidate polymorphism) at 1q23 (lod = 3.37 in African-Americans) is syntenic with linkage in a murine model of lupus. Sib-pair and multipoint nonparametric analyses also support linkage ( <jats:italic>P</jats:italic> < 0.05) at nine loci detected by using two-point lod score analysis (lod > 2.0). Our results are consistent with the presumed complexity of genetic susceptibility to SLE and illustrate racial origin is likely to influence the specific nature of these genetic effects. </jats:p>

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