Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate‐irritated skin
書誌事項
- 公開日
- 2008-07-17
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/j.1365-4632.2008.03687.x
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p><jats:bold>Background </jats:bold> Stratum corneum intercellular lipids, such as ceramides, play an important role in the regulation of skin water barrier homeostasis and water‐holding capacity.</jats:p><jats:p><jats:bold>Aim </jats:bold> To evaluate the potential water retention capacity of control emulsion and three oil‐in‐water (o/w) emulsions containing ceramide 1, ceramide 3, or both.</jats:p><jats:p><jats:bold>Methods </jats:bold> Fifteen healthy Asian women (age, 20–30 years) with healthy skin, pretreated with sodium lauryl sulfate (SLS), applied the tested emulsions twice daily over a period of 28 days. Skin hydration and transepidermal water loss (TEWL) values were measured on the indicated days with a Corneometer®825 and a TEWAMETER TM210, respectively.</jats:p><jats:p><jats:bold>Results </jats:bold> The maximum increase in skin humidity was reached after 4 weeks, with values of 21.9 ± 1.8% and 8.9 ± 0.9% for emulsion C and control emulsion, respectively. The maximum decrease in TEWL was also reached after 4 weeks, with values of 36.7 ± 4.7% and 5.1 ± 0.8% for the same emulsions.</jats:p><jats:p><jats:bold>Conclusions </jats:bold> It can be concluded that all the tested ceramide‐containing emulsions improved skin barrier function when compared with untreated skin. There was some indication that ceramides 1 and 3 contained in emulsion C might exert a beneficial synergistic effect on skin biochemical properties, such as skin hydration and TEWL, and play a key role in the protection mechanism against SLS irritation.</jats:p>
収録刊行物
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- International Journal of Dermatology
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International Journal of Dermatology 47 (8), 812-819, 2008-07-17
Wiley
