Efflux of Chloroquine from <i>Plasmodium falciparum</i> : Mechanism of Chloroquine Resistance
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- Donald J. Krogstad
- Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
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- Ilya Y. Gluzman
- Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
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- Dennis E. Kyle
- Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC 20307.
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- Ayoade M. J. Oduola
- Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC 20307.
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- Samuel K. Martin
- Division of Medicine, Walter Reed Army Institute of Research, Washington, DC 20307.
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- Wilbur K. Milhous
- Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC 20307.
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- Paul H. Schlesinger
- Department of Biomedical Research at Washington University School of Dental Medicine, St. Louis, MO 63110.
書誌事項
- 公開日
- 1987-11-27
- DOI
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- 10.1126/science.3317830
- 公開者
- American Association for the Advancement of Science (AAAS)
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説明
<jats:p> Chloroquine-resistant <jats:italic>Plasmodium falciparum</jats:italic> accumulate significantly less chloroquine than susceptible parasites, and this is thought to be the basis of their resistance. However, the reason for the lower accumulation of chloroquine was unknown. The resistant parasite has now been found to release chloroquine 40 to 50 times more rapidly than the susceptible parasite, although their initial rates of chloroquine accumulation are the same. Verapamil and two other calcium channel blockers, as well as vinblastine and daunomycin, each slowed the release and increased the accumulation of chloroquine by resistant (but not susceptible) <jats:italic>Plasmodium falciparum</jats:italic> . These results suggest that a higher rate of chloroquine release explains the lower chloroquine accumulation, and thus the resistance observed in resistant <jats:italic>Plasmodium falciparum</jats:italic> . </jats:p>
収録刊行物
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- Science
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Science 238 (4831), 1283-1285, 1987-11-27
American Association for the Advancement of Science (AAAS)
