Pathway and network analysis of cancer genomes
書誌事項
- 公開日
- 2015-06-30
- 権利情報
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- http://www.springer.com/tdm
- DOI
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- 10.1038/nmeth.3440
- 公開者
- Springer Science and Business Media LLC
この論文をさがす
説明
Genomic information on tumors from 50 cancer types cataloged by the International Cancer Genome Consortium (ICGC) shows that only a few well-studied driver genes are frequently mutated, in contrast to many infrequently mutated genes that may also contribute to tumor biology. Hence there has been large interest in developing pathway and network analysis methods that group genes and illuminate the processes involved. We provide an overview of these analysis techniques and show where they guide mechanistic and translational investigations.
収録刊行物
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- Nature Methods
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Nature Methods 12 (7), 615-621, 2015-06-30
Springer Science and Business Media LLC
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キーワード
- 570
- Technology
- 1303 Biochemistry
- Bioinformatics and Computational Biology
- 610
- Pathway and network analysis
- Mutation Consequences and Pathway Analysis Working Group of the International Cancer Genome Consortium
- Tumors -- Genètica
- Medical and Health Sciences
- 1307 Cell Biology
- Cancer Genomics
- Neoplasms
- 1312 Molecular Biology
- Genetics
- 2.1 Biological and endogenous factors
- Humans
- Gene Regulatory Networks
- Genomes
- Tumors
- Cancer
- Genome
- Prevention
- Human Genome
- Biological Sciences
- Biological sciences
- 1305 Biotechnology
- Driver genes
- Cancer genomes
- Genètica
- Developmental Biology
- Signal Transduction
詳細情報 詳細情報について
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- CRID
- 1361699995536866176
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- ISSN
- 15487105
- 15487091
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- HANDLE
- 10230/36284
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- PubMed
- 26125594
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- データソース種別
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- Crossref
- OpenAIRE