Pathway and network analysis of cancer genomes

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書誌事項

公開日
2015-06-30
権利情報
  • http://www.springer.com/tdm
DOI
  • 10.1038/nmeth.3440
公開者
Springer Science and Business Media LLC

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説明

Genomic information on tumors from 50 cancer types cataloged by the International Cancer Genome Consortium (ICGC) shows that only a few well-studied driver genes are frequently mutated, in contrast to many infrequently mutated genes that may also contribute to tumor biology. Hence there has been large interest in developing pathway and network analysis methods that group genes and illuminate the processes involved. We provide an overview of these analysis techniques and show where they guide mechanistic and translational investigations.

収録刊行物

  • Nature Methods

    Nature Methods 12 (7), 615-621, 2015-06-30

    Springer Science and Business Media LLC

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