Construction of the taxane skeleton via the stereoselective conjugate addition of cyanide and the intramolecular B-alkyl Suzuki–Miyaura coupling reaction
書誌事項
- 公開日
- 2007-09
- 権利情報
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- https://www.elsevier.com/tdm/userlicense/1.0/
- DOI
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- 10.1016/j.tetlet.2007.07.179
- 公開者
- Elsevier BV
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説明
Abstract Construction of the taxane skeleton via the stereoselective conjugate addition of cyanide and the intramolecular B-alkyl Suzuki–Miyaura coupling reaction is described. A conjugate addition of cyanide to enone 17 proceeded diastereoselectively to provide the desired 18 incorporating the correct C3 stereogenic center in the taxol C-ring. The intramolecular B-alkyl Suzuki–Miyaura coupling reaction of 22, which was derived from 18, successfully furnished the taxol B-ring in 81% yield.
収録刊行物
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- Tetrahedron Letters
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Tetrahedron Letters 48 (39), 6868-6872, 2007-09
Elsevier BV
