Alkynylation of C(O)–H Bonds Enabled by Photoredox‐Mediated Hydrogen‐Atom Transfer

Satobhisha Mukherjee, R. Aleyda Garza‐Sanchez, Adrian Tlahuext‐Aca, Frank Glorius

doi:10.1002/anie.201708037

Alkynylation of C(O)–H Bonds Enabled by Photoredox‐Mediated Hydrogen‐Atom Transfer

DOI Web Site Web Site 被引用文献8件

Satobhisha Mukherjee

Organisch-Chemisches Institut Westfälische Wilhelms-Universität Münster Corrensstrasse 40 48149 Münster Germany
R. Aleyda Garza‐Sanchez

Organisch-Chemisches Institut Westfälische Wilhelms-Universität Münster Corrensstrasse 40 48149 Münster Germany
Adrian Tlahuext‐Aca

Organisch-Chemisches Institut Westfälische Wilhelms-Universität Münster Corrensstrasse 40 48149 Münster Germany
Frank Glorius

Organisch-Chemisches Institut Westfälische Wilhelms-Universität Münster Corrensstrasse 40 48149 Münster Germany

書誌事項

公開日: 2017-10-11

権利情報

http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1002/anie.201708037

公開者: Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>The development of new hydrogen‐atom transfer (HAT) strategies within the framework of photoredox catalysis is highly appealing for its power to activate a desired C−H bond in the substrate leading to its selective functionalization. Reported here is the first photoredox‐mediated hydrogen‐atom transfer method for the efficient synthesis of ynones, ynamides, and ynoates with high regio‐ and chemoselectivity by direct functionalization of C<jats:inline-graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="graphic/anie201708037-math-0002.png" xlink:title="urn:x-wiley:14337851:media:anie201708037:anie201708037-math-0002"/> (O)−H bonds. The broad synthetic application of this method has been demonstrated by the selective functionalization of C(O)−H bonds within complex molecular scaffolds.</jats:p>