A transcriptional signature of hub connectivity in the mouse connectome
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- Ben D. Fulcher
- Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, 3168 VIC, Australia
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- Alex Fornito
- Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, 3168 VIC, Australia
説明
<jats:title>Significance</jats:title> <jats:p>Some brain regions are highly connected with other areas, designating them as network hubs. These hubs are also heavily interconnected with each other, forming a dense core that integrates information across different neural systems. Here, we show that the functionally important projections linking hub areas of the mouse brain have a distinct genetic signature that is characterized by the tightly coupled expression of genes regulating the synthesis and metabolism of ATP, the primary energy source for neural activity. Our findings establish a direct link between molecular function and the large-scale organization of neuronal connectivity and suggest that coordinated gene expression between hub areas is closely related to the metabolic demands of these highly active and functionally important regions.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 113 (5), 1435-1440, 2016-01-15
Proceedings of the National Academy of Sciences