Biosynthetic investigation of phomopsins reveals a widespread pathway for ribosomal natural products in Ascomycetes
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- Wei Ding
- Department of Chemistry, Fudan University, Shanghai 200433, China;
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- Wan-Qiu Liu
- Department of Chemistry, Fudan University, Shanghai 200433, China;
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- Youli Jia
- Department of Chemistry, Fudan University, Shanghai 200433, China;
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- Yongzhen Li
- Department of Chemistry, Fudan University, Shanghai 200433, China;
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- Wilfred A. van der Donk
- Department of Chemistry, University of Illinois at Urbana–Champaign, Urbana, IL 61801;
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- Qi Zhang
- Department of Chemistry, Fudan University, Shanghai 200433, China;
抄録
<jats:title>Significance</jats:title> <jats:p>Ascomycetes are a prolific source of natural products that are of great significance for human health, yet production of ribosomally synthesized and posttranslationally modified peptides (RiPPs), a ubiquitous class of natural products, have rarely been reported in this fungal phylum. Here we show that phomopsins, a family of antimitotic mycotoxins, have a ribosomal origin and demonstrate the widespread presence of a fungal RiPP pathway for cyclic peptides that we term dikaritins. The framework described herein provides a foundation for mining for additional dikaritin members and investigating the biological activities and biosynthetic chemistry of this family of fungal natural products.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 113 (13), 3521-3526, 2016-03-15
Proceedings of the National Academy of Sciences