Treatment and sampling protocols for transgenic mutation assays

John A. Heddle, Hans‐Joerg Martus, George R. Douglas

doi:10.1002/em.10131

Treatment and sampling protocols for transgenic mutation assays

DOI Web Site Web Site 被引用文献4件

書誌事項

公開日: 2003-01

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http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1002/em.10131

公開者: Wiley

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<jats:title>Abstract</jats:title><jats:p>The standard protocol for testing chemicals with the transgenic mutation assays in vivo includes a period of time between treatment and sampling to permit the mutation frequency to reach a maximum. Recent evidence has shown, however, that for some chemicals the mutant frequency can decline substantially during this period, which would reduce the sensitivity of the assay. Here we discuss alternate protocols to maintain the sensitivity of the assay for both types of mutagens and, in particular, propose that treatments should continue until the time of sampling. Environ. Mol. Mutagen. 41:1–6, 2003. © 2003 Wiley‐Liss, Inc.</jats:p>