Spatiotemporal structure of cell fate decisions in murine neural crest
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- Ruslan Soldatov
- Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
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- Marketa Kaucka
- Department of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria.
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- Maria Eleni Kastriti
- Department of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria.
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- Julian Petersen
- Department of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria.
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- Tatiana Chontorotzea
- Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.
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- Lukas Englmaier
- Department of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria.
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- Natalia Akkuratova
- Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.
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- Yunshi Yang
- Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.
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- Martin Häring
- Department of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska Institutet, 17177 Stockholm, Sweden.
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- Viacheslav Dyachuk
- Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden.
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- Christoph Bock
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
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- Matthias Farlik
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
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- Michael L. Piacentino
- Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
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- Franck Boismoreau
- Institut de Biologie de l’ENS (IBENS), INSERM, CNRS, École Normale Supérieure, PSL Research University, 75005 Paris, France.
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- Markus M. Hilscher
- Department of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska Institutet, 17177 Stockholm, Sweden.
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- Chika Yokota
- Science for Life Laboratory, Department of Biophysics and Biochemistry, Stockholm University, 17165 Solna, Sweden.
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- Xiaoyan Qian
- Science for Life Laboratory, Department of Biophysics and Biochemistry, Stockholm University, 17165 Solna, Sweden.
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- Mats Nilsson
- Science for Life Laboratory, Department of Biophysics and Biochemistry, Stockholm University, 17165 Solna, Sweden.
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- Marianne E. Bronner
- Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
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- Laura Croci
- San Raffaele Scientific Institute and Università Vita-Salute San Raffaele, 20132, Milan, Italy.
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- Wen-Yu Hsiao
- Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
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- David A. Guertin
- Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
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- Jean-Francois Brunet
- Institut de Biologie de l’ENS (IBENS), INSERM, CNRS, École Normale Supérieure, PSL Research University, 75005 Paris, France.
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- Gian Giacomo Consalez
- San Raffaele Scientific Institute and Università Vita-Salute San Raffaele, 20132, Milan, Italy.
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- Patrik Ernfors
- Department of Medical Biochemistry and Biophysics, Division of Molecular Neurobiology, Karolinska Institutet, 17177 Stockholm, Sweden.
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- Kaj Fried
- Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden.
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- Peter V. Kharchenko
- Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
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- Igor Adameyko
- Department of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria.
説明
<jats:title>Binary decisions refine fate decisions</jats:title> <jats:p> Neural crest cells develop into tissues ranging from craniofacial bones to peripheral neurons. Combining single-cell RNA sequencing with spatial transcriptomics, Soldatov <jats:italic>et al.</jats:italic> analyzed how neural crest cells in mouse embryos decide among the various fates available to them (see the Perspective by Mayor). These multipotent cells become biased toward a given fate early on and step through a progression of binary decisions as their fate is refined. Competing fate programs coexist until increased synchronization favors one and repression disfavors the other. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aas9536">eaas9536</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6444" page="937" related-article-type="in-this-issue" vol="364" xlink:href="10.1126/science.aax7917">937</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 364 (6444), 2019-06-07
American Association for the Advancement of Science (AAAS)