Intracellular calcium release channels: an update

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  • Gaetano Santulli
    The Wu Center for Molecular Cardiology Columbia University New York NY USA
  • Ryutaro Nakashima
    The Wu Center for Molecular Cardiology Columbia University New York NY USA
  • Qi Yuan
    The Wu Center for Molecular Cardiology Columbia University New York NY USA
  • Andrew R. Marks
    The Wu Center for Molecular Cardiology Columbia University New York NY USA

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<jats:title>Abstract</jats:title><jats:p>Ryanodine receptors (RyRs) and inositol 1,4,5‐trisphosphate receptors (IP<jats:sub>3</jats:sub>Rs) are calcium (Ca<jats:sup>2+</jats:sup>) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we summarize the latest advances in the field, describing the recently discovered mechanistic roles of intracellular Ca<jats:sup>2+</jats:sup> release channels in the regulation of mitochondrial fitness and endothelial function, providing novel therapeutic options for the treatment of heart failure, hypertension, and diabetes mellitus. <jats:boxed-text content-type="graphic" position="anchor"><jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" mimetype="image/png" position="anchor" specific-use="enlarged-web-image" xlink:href="graphic/tjp12337-gra-0001-m.png"><jats:alt-text>image</jats:alt-text></jats:graphic></jats:boxed-text> </jats:p>

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